Preparation of body-temperature-triggered shape-memory polyurethane with biocompatibility using isosorbide and castor oil |
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| Institution: | 1. Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan;2. Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan;3. School of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China;4. Department of Chemistry, Government Postgraduate College Samanabad, Faisalabad 38000, Pakistan;1. School of Automotive Engineering, Wuhan University of Technology, Wuhan 430070, China;2. School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China;3. Hubei Key Laboratory of Advanced Technology for Automotive Components (Wuhan University of Technology), Wuhan 430070, China;4. Hubei Collaborative Innovation Center for Automotive Components Technology, Wuhan 430070, China;5. Hubei Research Center for New Energy & Intelligent Connected Vehicle, Wuhan University of Technology, Wuhan 430070, China;1. School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, P.R. China;2. Department of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China;3. You Pei College, Yancheng Institute of Technology, Yancheng 224051, P.R. China;4. School of Mechanical Engineering, Yancheng Institute of Technology, Yancheng 224051, P.R. China |
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| Abstract: | Shape memory polyurethanes (SMPUs) have attracted much attention in the biomedical field because they can easily control the transition temperature (Ttrans) to shape memory and are biocompatible. In this study, a shape memory polyurethane with both biocompatibility and a Ttrans close to the body temperature was synthesized by using natural derivatives of isosorbide and castor oil in place of petroleum-based materials. Isosorbide and castor oil were used to form net points, and polycaprolactone diol (PCL diol) acted as the switching segment. The synthesized four polyurethane (PCL diol/isosorbide/castor oil, PICU-1, 2, 3, 4) with different isosorbide contents exhibited desired thermal and mechanical properties. In the thermo-cyclic shape memory testing experiment, the PICU series demonstrated good shape memory property, with more than 95% shape recovery ratio (Rr) and more than 90% shape fixity ratio (Rf), and PICU-3 recovered its shape within 20 s in a 37 °C water bath. In addition, the PICU series proved to be safe materials with excellent biocompatibility, as indicated by the observed C2C12 cells viability and proliferation. The stent made with the PICU-3 film showed near complete magnetization at 37 °C within 18 s and proved to be a suitable self-expanding stent. |
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| Keywords: | Shape memory polyurethanes (SMPUs) Isosorbide Castor oil Biocompatibility Self-expandable stent |
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