Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction |
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| Authors: | Tavagnacco Claudio Monari Stefano Ranieri Antonio Bortolotti Carlo Augusto Peressini Silvia Borsari Marco |
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| Affiliation: | Department of Chemistry, University of Trieste, via Giorgieri 1, I-34127 Trieste, Italy. |
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| Abstract: | Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress. |
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