Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA |
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| Authors: | Gupta Pankaj Zengeya Thomas Rozners Eriks |
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| Institution: | Department of Chemistry, Binghamton University, The State University of New York, Binghamton, New York 13902, USA. |
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| Abstract: | Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA. |
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