A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine |
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| Authors: | Ge Jingyan Li Lin Yao Shao Q |
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| Institution: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore. |
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| Abstract: | Synthesis of the first self-immobilizing, fluorogenic unnatural amino acid that mimics phosphotyrosine (pTyr) is reported. By using solid-phase peptide synthesis, it was subsequently incorporated into peptide-based probes which found applications in bioimaging and fluorescence-activated cell sorting (FACS). |
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