DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy |
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| Authors: | Papadopoulou Evanthia Bell Steven E J |
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| Affiliation: | Innovative Molecular Materials Group, School of Chemistry and Chemical Engineering, Queen's University, Belfast, BT9 5AG, UK. |
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| Abstract: | DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon. |
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