Novel hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the water-soluble phosphane 1,3,5-triaza-7-phosphaadamantane: Synthesis and evaluation of DNA binding properties |
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| Authors: | Almudena García-Fernández Josefina Díez Ángel Manteca Jesús Sánchez M Pilar Gamasa Elena Lastra |
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| Institution: | 1. Departamento de Química Orgánica e Inorgánica, Instituto de Química Organometálica “Enrique Moles” (Unidad Asociada al C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain;2. Departamento de Biología Funcional, Instituto Universitario de Biotecnología de Asturias, Área de Microbiología, Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain |
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| Abstract: | A series of half-sandwich ruthenium(II) complexes containing κ3(N,N,N)-hydridotris(pyrazolyl)borate (κ3(N,N,N)-Tp) and the water-soluble phosphane 1,3,5-triaza-7-phosphaadamantane (PTA) RuX{κ3(N,N,N)-Tp}(PPh3)2−n(PTA)n] (n = 2, X = Cl (1), n = 1, X = Cl (2), I (3), NCS (4), H (5)) and Ru{κ3(N,N,N)-Tp}(PPh3)(PTA)L]PF6] (L = NCMe (6), PTA (7)) have been synthesized. Complexes containing 1-methyl-3,5-diaza-1-azonia-7-phosphaadamantane(m-PTA) triflate RuCl{κ3(N,N,N)-Tp}(m-PTA)2]CF3SO3]2 (8) and RuX{κ3(N,N,N)-Tp}(PPh3)(m-PTA)]CF3SO3] (X = Cl (9), H (10)) have been obtained by treatment, respectively, of complexes 1, 2 and 5 with methyl triflate. Single crystal X-ray diffraction analysis for complexes 1, 2 and 4 have been carried out. DNA binding properties by using a mobility shift assay and antimicrobial activity of selected complexes have been evaluated. |
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| Keywords: | Water-soluble ruthenium(II) complexes Hydridotris(pyrazolyl)borate PTA DNA binding Microbial cytotoxicity |
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