| 银杏酸的合成新方法 |
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| 引用本文： | 赵剑阳,王婷,刘情情,朱槿,黄晴菲,王启卫.银杏酸的合成新方法[J].合成化学,2016,24(4):359-361. |
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| 作者姓名： | 赵剑阳 王婷 刘情情 朱槿 黄晴菲 王启卫 |
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| 作者单位： | 1. 中国科学院 成都有机化学研究所，四川 成都 610041； 2. 中国科学院大学，北京 100049 |
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| 基金项目： | 成都市高新区创新创业人才奖 |
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| 摘 要： | 报道了一种合成银杏酸类化合物的新方法。以2-羟基-5-甲基苯甲酸为起始原料，经甲基化和溴代反应后，通过Wittig反应构建不同链长侧链合成了2-甲氧基-6-十三碳-1-烯基苯甲酸甲酯(6a)和2-甲氧基-6-十五碳-1-烯基苯甲酸甲酯(6b)；用钯碳氢化还原6中的碳碳双键后脱除甲基合成了两种不同链长银杏酸，总收率分别为46%和40%，其结构经1H NMR和ESI-MS确证。
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| 关 键 词： | 2-羟基-5-甲基苯甲酸 银杏酸 Wittig反应 脱甲基 药物合成 |
| 收稿时间： | 2015-11-30 |
A Novel Synthetic Method for Ginkgolic Acid |
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| ZHAO Jian-yang,WANG Ting,LIU Qing-qing,ZHU Jin,HUANG Qing-fei,WANG Qi-wei.A Novel Synthetic Method for Ginkgolic Acid[J].Chinese Journal of Synthetic Chemistry,2016,24(4):359-361. |
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| Authors: | ZHAO Jian-yang WANG Ting LIU Qing-qing ZHU Jin HUANG Qing-fei WANG Qi-wei |
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| Institution: | 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A novel method for the synthesis of the ginkgolic acid was reported.2-Methoxy-6-tridec-1-enylbenzoic acid methyl este (6a) and 2-methoxy-6-pentadec-1-enylbenzoic acid methyl ester (6b) were synthesized by methlation, N-bromosuccinimide substitution and constructing different long chain olefins via Wittig reaction from 2-methy-5-hydroxy benzoic acid.Two ginkgolic acids with different long chains were synthesized by reduction of carbon carbon double bond of 6 with palladium carbon then demethylating, the total yield were 46% and 40%, respectively.The structures were confirmed by 1 H NMR and ESI-MS. |
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| Keywords: | 2-methy-5-hydroxy benzoic acid ginkgolic acid Wittig reaction demethylation drug synthesis |
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