| 新型2-取代氨基-3-氟-4-吡啶氟硼酸钾盐的合成 |
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| 引用本文： | 滕明刚,赵春深,段炼,柴慧芳. 新型2-取代氨基-3-氟-4-吡啶氟硼酸钾盐的合成[J]. 合成化学, 2016, 24(4): 316-320. DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.04.15146 |
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| 作者姓名： | 滕明刚 赵春深 段炼 柴慧芳 |
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| 作者单位： | 1. 贵阳中医学院 药学院， 贵州 贵阳 550002； 2. 贵州大学 药学院， 贵州 贵阳 550025 |
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| 基金项目： | 贵州省高层次人才科研条件特助经费项目(TZJF-2010年-055号)，贵州省教育厅自然科学研究项目(黔教合KY字[2012]044号)，贵州省社发攻关项目(黔科合SY字[2014]3054号) |
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| 摘 要： | 以2,3-二氟-5-氯吡啶为原料，依次经取代和还原反应制得2-取代氨基-3-氟吡啶化合物(2a~2g)； 2a~2g与正丁基锂及硼酸三异丙酯经有机锂化法制得相应的硼酸化合物(3a~3g)； 3a~3g分别与氟化氢钾经取代反应合成了7个新型的2-取代氨基-3-氟-4-吡啶氟硼酸钾盐，其结构经1H NMR, 13C NMR, IR, ESI-MS和元素分析表征。
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| 关 键 词： | 2 3-二氟-5-氯吡啶 2-取代氨基-3-氟-4-吡啶氟硼酸钾盐 合成 |
| 收稿时间： | 2014-03-10 |
Synthesis of Novel Potassium( 3-fluoro-2-amino substituted pyridin-4-yltrifluoroborates) |
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| TENG Ming-gang,ZHAO Chun-shen,DUAN Lian,CHAI Hui-fang. Synthesis of Novel Potassium( 3-fluoro-2-amino substituted pyridin-4-yltrifluoroborates)[J]. Chinese Journal of Synthetic Chemistry, 2016, 24(4): 316-320. DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.04.15146 |
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| Authors: | TENG Ming-gang ZHAO Chun-shen DUAN Lian CHAI Hui-fang |
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| Affiliation: | 1. Department of Pharmacy, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China; 2. School of Pharmacy, Guizhou University, Guiyang 550025, China |
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| Abstract: | 2-Substituted-amino-3-fluoropyridine compounds(2a~2g) were synthesized by substitution and reduction from 2,3-difluoro-5-chloropyridine.A series of pyridine boric acid compounds(3a~3g) were obtained by reaction of 2 with n-butyllithium and triisopropyl borate.Finally, seven novel potassi-um(3-fluoro-2-amino substituted pyridin-4-yltrifluoroborates) were synthesized by substitution of 3a~3g with potassium hydrogen fluoride, respectively.The structures were characterized by 1 H NMR, 13 C NMR, IR, ESI-MS and elemental analysis. |
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| Keywords: | 5-chloro-2 3-difluoropyridine potassium ( 3-fluoro-2-amino substitutedpyridin-4-yltriflu-oroborate) synthesis |
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