| 异色满并[4,3-b]喹啉衍生物的合成 |
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| 引用本文： | 纪建业,王鲁敏,王进军.异色满并[4,3-b]喹啉衍生物的合成[J].化学研究与应用,2006,18(3):313-315. |
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| 作者姓名： | 纪建业 王鲁敏 王进军 |
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| 作者单位： | 通化师范学院化学系,吉林,通化,134002;烟台大学应用化学系,山东,烟台,265005 |
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| 摘 要： | 早在1931年,Hetherington等从念珠状曲菌(Aspergillus Cand inin)和土曲菌(Asperillus tereus)等菌类中分离出带有异色满(Isochroman)环系结构的左旋抗菌素橘霉素(C itrinin),后来又相继发现诸多带有异色满环系的天然产物1-3],新近在软木木质素中也发现了多种具有异色满结构的
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| 关 键 词： | 异色满酮-4 异色满并喹啉 缩合反应 合成 |
| 文章编号： | 1004-1656（2006）03-0313-03 |
| 收稿时间： | 2005-04-13 |
| 修稿时间： | 2005-06-18 |
Synthesis of isochromano[4,3-b]quinoline derivatives |
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| JI Jina-ye,Wang Lu-min,WANG Jin-jun.Synthesis of isochromano[4,3-b]quinoline derivatives[J].Chemical Research and Application,2006,18(3):313-315. |
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| Authors: | JI Jina-ye Wang Lu-min WANG Jin-jun |
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| Institution: | 1. Department of Chemistry,Tonghua Teachers College,Tonghua 134002;2. Department of Applied Chemistry, Yantai University, Yantai 264005 |
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| Abstract: | Isochrom anone-4 1 was used as a starting m aterial and Pfitzinger reaction was carried out by condensation w ith isatin 2 to give 7-carboxyl group isochrom ano4,3-b] qu inoline 3 whose ester 4 was obtained by treatm ent w ith d iazom ethane.A fter the G rignard reaction of 4 w ith m ethylm agnesium brom ide the m ethoxycarbonyl group was converted into the tertiary alcohol structure to generate isochrom an derivative 5.The dehydration of hydroxyl group at 7-position of 5 using TsOH as catalyst afforded dehydrated product 6.The structures of all these new compounds were characterized by elem ental analysis,IR and1H NMR spectra. |
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| Keywords: | isochromanone-4 isochroman-fused heterocyclic compound condensation synthesis |
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