Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support |
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| Authors: | Paterson Ian Gottschling Dirk Menche Dirk |
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| Affiliation: | University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk |
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| Abstract: | By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A). |
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