Distinguishing malignant from normal stomach tissues and its <Emphasis Type="Italic">in vivo,in situ</Emphasis> measurement in operating process using FTIR Fiber-Optic techniques |
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Authors: | Yizhuang?Xu Limin?Yang Zhi?Xu Ying?Zhao Xiaofeng?Ling Qingbo?Li Jiansheng?Wang Nengwei?Zhang Yuanfu?Zhang Email author" target="_blank">Jinguang?WuEmail author |
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Institution: | (1) The State Key Laboratory of Rare Earth Materials and Applications, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;(2) Institute of Chemistry, Chinese Academy of Sciences, 100080 Beijing, China;(3) Department of Surgery, Third Hospital, Peking University, 100083 Beijing, China;(4) Department of Oncology Surgery, the First Hospital of Xi’an, Jiaotong University, 710061 Xi’an, China |
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Abstract: | Gastric tissue samples were studied using mid-IR fiber-optic attenuated total reflectance (ATR) spectroscopy. FTIR spectra
of 90 tissue samples from 48 patients, including 32 normal and 58 malignant tissue samples, were chosen as examples. Malignancy
was usually characterized by the absence of CH and C=O bands, a weak amide II band near 1545 cm-1, a shift of the amide I band to lower wave number, a decrease in the ∼1450 cm-1 peak to less than the ∼ 1400 cm-1 peak. Subtraction spectra indicate that the amide I and amide II bands of normal and malignant tissues have larger differences
in peak positions and relative intensities. The statistical analysis results confirm this conclusion. The results indicate
that FTIR fiber optic techniques provide important information about cancerous tissue of the stomach, which can be used to
differentiate the malignant tissue from the normal tissue. Based on the above results we successfully realize the detection
of the tumor tissues of digestive tract in vivo and in situ. And the results of detection cancer near operating room and in vivo and in situ in the operating room are consistent with the conclusions for the samples stored in liquid N2, which is the basis for the clinical application. |
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Keywords: | FTIR Fiber-Optics stomach tissues cancer diagnosis |
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