Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae) |
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Authors: | Muktar Mat Ropi Osman Norfaizah Awang Khalijah Hazni Hazrina Qureshi Ahmad Kaleem Hadi A Hamid A Zaima Kazuma Morita Hiroshi Litaudon Marc |
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Institution: | Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. matropi@um.edu.my |
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Abstract: | A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10(-5) M. |
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