Efficient synthesis of 5-amido-3-hydroxy-4-pyrones as inhibitors of matrix metalloproteinases |
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| Authors: | Yan Yi-Long Cohen Seth M |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA. |
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| Abstract: | 3-hydroxy-4-pyrones are a class of important metal chelators with versatile medicinal applications. An efficient pathway for the preparation of new 5-amido-3-hydroxy-4-pyrone derivatives has been developed. The synthesized 5-amido-3-hydroxy-4-pyrones have been evaluated as inhibitors of matrix metalloproteinases. |
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