Thermodynamic Study of the Solubility of Benzocaine in some Organic and Aqueous Solvents |
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| Authors: | Carolina M Ávila Fleming Martínez |
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| Institution: | (1) Department of Pharmacy, National University of Colombia, A.A. 14490 Bogotá D.C., Colombia |
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| Abstract: | The thermodynamic functions free energy, enthalpy, and entropy of solution, were evaluated from solubility data of benzocaine determined at several temperatures in octanol, water, and the mutually saturated solvents, in isopropyl myristate, water, and the mutually saturated solvents, and in cyclohexane. In aqueous media the solubility was determined at pH 7.4 and ionic strength 0.15 mol-L–1. The excess free energy and the activity coefficients of the solutes also were determined. The solubility was higher in organic media, such as octanol and isopropyl myristate, than in aqueous media and cyclohexane. |
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| Keywords: | Benzocaine solubility solution thermodynamics activity coefficients partial miscibility |
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