Structural diversity and versatility for organoaluminum complexes supported by mono- and di-anionic aminophenolate bidentate ligands

The present contribution describes the synthesis and structural characterization of structurally diverse organoaluminum species supported by variously substituted aminophenolate-type ligands: these Al complexes are all derived from the reaction of AlMe₃ with aminophenols 2-CH₂NH(R)-C₆H₃OH (1a, R = mesityl (Mes); 1b, R = 2,6-di-isopropylphenyl (Diip)) and 2-CH₂NH(R)-4,6-^tBu₂-C₆H₂OH (1c, R = Mes; 1d, R = Diip). The low temperature reaction of AlMe₃ with 1a–b readily affords the corresponding Al dimeric species μ-η¹,η¹-N,O-{2-CH₂NH(R)-C₆H₄O}]₂Al₂Me₄ (2a–b), consisting of twelve-membered ring aluminacycles with two μ-η¹,η¹-N,O-aminophenolate units, as determined by X-ray crystallographic studies. Heating a toluene solution of 2a (80 °C, 3 h) affords the quantitative and direct formation of the dinuclear aluminium complex Alη²-N; μ,η²-O-{2-CH₂N(Mes)-C₆H₄O}](AlMe₂) (4a) while species 2b, under the aforementioned conditions, affords the formation of the Al dimeric species η²-N,O-{2-CH₂N(Dipp)-C₆H₄O}AlMe]₂ (3b), as deduced from X-ray crystallography for both 3b and 4a. In contrast, the reaction of bulky aminophenol pro-ligands 1c–d with AlMe₃ afford the corresponding monomeric Al aminophenolate chelate complexes η²-N,O-{2-CH₂NH(R)-4,6-^tBu₂-C₆H₂O}AlMe₂ (5c–d; R = Mes, Diip; Scheme 3) as confirmed by X-ray crystallographic analysis in the case of 5d. Subsequent heating of species 5c–d yields, via a methane elimination route, the corresponding Al-THF amido species η²-N,O-{2-CH₂N(R)-4,6-^tBu₂-C₆H₂O}Al(Me)(THF) (6c–d; R = Mes, Diip). Compounds 6c–6d, which are of the type {X₂}Al(R)(L) (L labile), may well be useful as novel well-defined Lewis acid species of potential use for various chemical transformations. Overall, the sterics of the aminophenol backbone and, to a lesser extent, the reaction conditions that are used for a given ligand/AlMe₃ set essentially govern the rather diverse “structural” outcome in these reactions, with a preference toward the formation of mononuclear Al species (i.e. species 5c–d and 6c–d) as the steric demand of the chelating N,O-ligand increases.