Synthesis,structure and cytotoxicity studies on diorganotin (R = Me,Et) complexes of N-methylpyridoxine (MePN,PN = Vitamin B6) containing different anions |
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| Authors: | José S Casas María D Couce Agustin Sánchez José Sordo Ezequiel M Vázquez López |
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| Institution: | 1. Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain;2. Departamento de Química Inorgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain |
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| Abstract: | The interaction of dimethyl- and diethyltin(IV) cations with methylpyridoxine iodide (MePN]I; PN = pyridoxine) was studied in ethanol/water (80:20(v/v) containing Cl?, NO3? or I? ions in different molar ratios. Several compounds containing the deprotonated (MePN-H) or neutral (MePN) ligand were isolated and characterized by elemental analysis, IR and NMR (1H, 13C, 119Sn) spectroscopy and FAB mass spectrometry. The compounds SnMe2(MePN-H)](I3), SnEt2(MePN-H)](I3), SnMe2(MePN-H)(NO3)], SnEt2(MePN-H)(NO3)] and SnMe2(MePN)2]I2 were studied by X-ray diffractometry. The compounds in which the MePN-H ligand is present can be described as containing dinuclear SnR2(MePN-H)]22+ (R = Me, Et) units, in which two bridging chelating methylpyridoxinato ligands link two metal atoms. Interactions also exist between the metal and the I3? or NO3? anions and these interactions differ in degree and type. On the other hand, in the only example of a complex containing the MePN ligand, the mononuclear SnMe2(MePN)2]2+ unit is present. The in vitro antitumor activity of these complexes against the HeLa, A2780 and A2780cis cell lines was determined and compared with that of the equivalent PN derivatives. |
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