| Crystal Structure and Inhibitory Activity against Xanthine Oxidase of Bis(μ_2-chloro)-chloro-(μ-N,N'-(2-pyridylmethylene) Furanmethanoamine Copper(II) Complex |
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| 引用本文： | 方瑞琴,史大华,石磊,朱海亮.Crystal Structure and Inhibitory Activity against Xanthine Oxidase of Bis(μ_2-chloro)-chloro-(μ-N,N'-(2-pyridylmethylene) Furanmethanoamine Copper(II) Complex[J].结构化学,2008(3). |
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| 作者姓名： | 方瑞琴 史大华 石磊 朱海亮 |
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| 作者单位： | Institute of Functional Biomolecules State Key Laboratory of Pharmaceutical Biotechnology Nanjing University，Institute of Functional Biomolecules，State Key Laboratory of Pharmaceutical Biotechnology Nanjing University，Institute of Functional Biomolecules，State Key Laboratory of Pharmaceutical Biotechnology Nanjing University，Institute of Functional Biomolecules，State Key Laboratory of Pharmaceutical Biotechnology Nanjing University，Nanjing 210093，China，Nanjing 210093，China，Nanjing 210093，China，Nanjing 210093，China |
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| 基金项目： | the National Natural Science Foundation of China (No. 649620) |
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| 摘 要： | A chloro-bridged dinuclear copper(II) complex with ligand 2-pyridylme-thylene-furfurylamine has been synthesized and characterized by single-crystal X-ray diffraction, and its inhibitory activity on xanthine oxidase (XO) was also evaluated. It crystallizes in the triclinic system, space group P1 with a=8.0441(16), b=8.5663(17), c=10.060(2), α=77.52(3), β= 72.04(3), γ=70.12(3)°, V=615.3(2)3, Z=1, Dc=1.731 g/cm3, F(000)=322, the final R= 0.0401 and wR=0.0934 for 1971 observed reflections with I > 2σ(I). X-ray analysis reveals that the Cu(II) cation is five-coordinated by two N atoms of Schiff base and three Cl anions. The C-H…Cl intermolecular and intramolecular hydrogen bonds connect the molecules to form a three-dimensional network. This copper(II) complex shows more potent inhibitory activity against XO with IC50=3.48 μM than the standard inhibitor allopurinol.
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