Urinary metabolites of genistein administered orally to rats. |
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Authors: | T Yasuda J Ueda K Ohsawa |
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Institution: | Tohoku Pharmaceutical University, Sendai, Miyagi, Japan. |
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Abstract: | In a study on the metabolism of flavonoids, the isoflavone genistein was administered orally to rats. Urine samples were collected and treated with beta-glucuronidase and arylsulfatase. Genistein and its metabolites, 4',5,7-trihydroxyisoflavanone (M1), 4',7-dihydroxyisoflavan (M2), and p-ethylphenol (M3) were isolated from the urine following treatment with enzymes. The structures of M1, M2, and M3 were determined on the basis of chemical and spectral data. |
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