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Generation of characteristic profiles of steroid hormones by reversed-phase HPLC |
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| Authors: | E V Obedkova L A Kartsova D O Kirsanov L I Velikanova A V Legin |
| Institution: | 1. Department of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Staryi Petergof, St. Petersburg, 198504, Russia 2. Mechnikov North-Western State Medical University, ul. Kirochnaya 41, St. Petersburg, 191015, Russia |
| Abstract: | A method for the determination of steroid hormones by reversed-phase HPLC has been applied to the analysis of biological fluids from healthy individuals and patients with endocrine systems diseases. The obtained chromatographic profiles were processed by the method of principal component analysis and method of soft independent modeling of class analogy. The principle possibility of using the results of chemometric processing of the chromatographic profiles as an additional diagnostic criterion for the treatment of some endocrine pathologies has been shown. |
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