A contribution to the asymmetric synthesis of isoquinolines: Concise stereoselective approach to (3S,4S)-6,7-dimethoxy-4-hydroxy-3-phenyl-1,2,3,4-tetrahydroisoquinoline |
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Institution: | 1. Graduate School of Innovative Life Science, University of Toyama, Japan;2. Graduate School of Science and Engineering, University of Toyama, Japan;3. Faculty of Engineering, University of Toyama, Japan;4. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan;5. School of Pharmacy, Showa University, Japan;1. Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan;2. Central Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Soka, Saitama 340-0003, Japan;1. European Molecular Biology Laboratory, Grenoble Outstation, Grenoble Cedex 9, France;2. Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma, Darwin 3, 28049 Madrid, Spain |
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Abstract: | A highly efficient stereoselective synthesis of (3S,4S)-6,7-dimethoxy-4-hydroxy-3-phenyl-1,2,3,4-tetrahydroisoquinoline 8 (e.e.=96%) starting from enantiomerically pure imine 3 is reported. |
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