Asymmetric dihydroxylation reactions leading to novel chiral ferrocene derivatives |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, China;2. School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255000, China;1. Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China;2. Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China;1. Boreskov Institute of Catalysis SB RAS, Pr. Akademika Lavrentieva 5, Novosibirsk, 630090, Russia;2. Novosibirsk State University, Pirogova Str. 2, Novosibirsk, 630090, Russia;1. State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, School of Pharmaceutical Science and Institute of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, 450001, PR China;2. China Meheco Topfond Pharmaceutical Co., Zhumadian, 463000, PR China |
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| Abstract: | Several ferrocenyl alkenes were used as starting materials for asymmetric dihydroxylation reactions. Although they turned out to be unreactive employing Sharpless' standard conditions, by systematic variation of the reaction conditions the desired novel ferrocenyl diols could be obtained in good yields and in enantiomeric excesses up to >99%. |
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