Assigning the absolute configuration of fumonisins by the circular dichroism exciton chirality method |
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| Institution: | 1. School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd., Shanghai 200240, China;2. Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA;1. Department of Mathematics, Furman University, Greenville, SC 29613, United States;2. Department of Mathematics and Computer Science, Dickinson College, Carlisle, PA 17013, United States;1. School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114,China;2. CAC Nantong Chemical Co., Ltd, Nantong 226407,China;1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University, Shanghai 200241, China;2. Department of Research and Development, Jiangsu Jiaerke Pharmaceuticals Group Co., Ltd., Zhenglu Town, Changzhou 213111, China;3. ECNU-JIAERKE Pharm. Steroids Green Manufacturing Laboratory, East China Normal University, Shanghai 200241, China |
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| Abstract: | Fumonisins are mycotoxins produced by Fusarium moniliforme (Sheldon) and other related fungi that are common contaminants of corn and other grains throughout the world. The circular dichroism (CD) exciton chirality method was applied to determine the absolute configuration of the terminal part of the backbone of fumonisins. Using the p-dimethylaminobenzoate chromophore, the structure of FB1 was confirmed to be 2S, 3S and 5R, while that of FB3 is described for the first time to be 2S and 3S. |
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