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The first Lewis acid mediated asymmetric Torgov cyclisation
Affiliation:1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China;2. College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China;1. Key Laboratory of Synthetic and Biological Colloid, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China;2. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China;3. Hangzhou Qingyue Pharmaceutical Technology Co. Ltd., Xixi Road Hangzhou, Zhejiang Province, China;4. Dalian Wondersun Biochemical Technology Co. LTD., Double D4 Street, Development Zone, Dalian 116600, Liaoning Province, China;1. Shanghai Key Laboratory of New Drug Design & School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China;2. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China
Abstract:The first catalytic enantioselective Torgov cyclisation has been achieved in 72% yield and up to 70% ee by using a chirally modified Ti complex. The new bis-steroidal ligands were found to be clearly superior to BINOL.
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