Asymmetric synthesis of functionalized piperidine derivatives: synthesis of (S)-anatabine |
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| Affiliation: | 1. Department of Medicine, Minneapolis Medical Research Foundation, 701 Park Ave., Minneapolis, MN 55415, United States;2. Department of Medicine, University of Minnesota School of Medicine, 420 Delaware St. SE, Minneapolis, MN 55455, United States;3. Department of Psychology, University of Minnesota, N218 Elliot Hall, 75 E River Rd., Minneapolis, MN 55455, United States;1. Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA |
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| Abstract: | A short and efficient chiral synthesis of 6-aryl-5-phenylsulfonyl-1,2,5,6-tetrahydropyridines was achieved in moderate yield and with good selectivity. The absolute configurations were assigned by extending the methodology to (S)-anatabine and as well with NMR experiments. |
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