Highly diastereoselective synthesis of two analogues of dihydrosphingosine |
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| Affiliation: | 1. College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China;2. Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | Diastereomeric analogues 8 and 9 of dihydrosphingosine 2 with a shortened alkyl chain were obtained with high diastereoselectivity via addition of n-hexyl magnesium bromide or dihexylzinc to a chiral aldehyde 3, respectively. These compounds are precursors of new potentially hydrosoluble analogues of glycosphingolipides. |
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