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Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands |
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| Affiliation: | 1. Department of Chemistry, Rajaram College, Kolhapur, 416004 Maharashtra, India;2. Department of Chemistry, Dr. Ghali College, Gadhinglaj, 416502 Maharashtra, India;3. CSIR—Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500007 Telangana, India;4. Department of Chemistry, R.B Madkholkar Mahavidyalaya, Chandgad, 416509 Maharashtra, India |
| Abstract: | Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/2b derived from (R)/(S)-phenylglycinol or enantioselective reduction of 4-[η6-chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborolidine followed by amine introduction to furnish optically active diarylmethylamines. |
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