New results on the melting thermodynamics of a circular DNA chain |
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Authors: | A. Kabakç ?o?lu,E. Orlandini |
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Affiliation: | a Department of Physics, Koç University, Sar?yer 34450 ?stanbul, Turkey b Dipartimento di Fisica, CNISM and Sezione INFN, Universita’ di Padova, Via Marzolo 8, 35131 Padova, Italy c Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel |
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Abstract: | We investigate the impact of supercoil period and nonzero supercoil formation energy on the thermal denaturation of a circular DNA. Our analysis is based on a recently proposed generalization of the Poland-Scheraga model that allows the DNA melting to be studied for plasmids with circular topology, where denaturation is accompanied by formation of supercoils. We find that the previously obtained first-order melting transition persists under the generalization discussed. The dependence of the size of the order-parameter jump at the transition point and the associated melting temperature are obtained analytically. |
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Keywords: | DNA denaturation Circular DNA Supercoil |
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