Quantification of growth asymmetries in developing epithelia |
| |
Authors: | T Bittig O Wartlick M González-Gaitán and F Jülicher |
| |
Institution: | 1.Max Planck Institute for the Physics of Complex Systems,Dresden,Germany;2.Department of Biochemistry and Department of Molecular Biology,Geneva University, Sciences II,Geneva 4,Switzerland |
| |
Abstract: | Many developmental processes of multicellular organisms involve the patterning and growth of two-dimensional tissues, so called
epithelia. We have quantified the growth of the wing imaginal disk, which is the precursor of the adult wing, of the fruit
fly Drosophila melanogaster. We find that growth follows a simple rule with exponentially decreasing area growth rate. Anisotropies of growth can be
precisely determined by comparing experimental results to a continuum theory. Growth anisotropies are to good approximation
constant in space and time. They are weak in wild-type wing disks but threefold increased in GFP-Dpp disks in which the morphogen
Dpp is overexpressed. Our findings indicate that morphogens such as Dpp control tissue shape via oriented cell divisions that
generate anisotropic growth. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|