| 人面果树皮中口 山 酮 化合物及其DPPH自由基的清除活性 |
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| 引用本文： | 钟芳芳a,陈玉b,王平a,冯慧瑾c,杨光忠a. 人面果树皮中口 山 酮 化合物及其DPPH自由基的清除活性[J]. 中国化学, 2009, 27(1): 74-80. DOI: 10.1002/cjoc.200990029 |
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| 作者姓名： | 钟芳芳a 陈玉b 王平a 冯慧瑾c 杨光忠a |
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| 作者单位： | (a中南民族大学 生命科学学院 天然产物化学研究室，湖北 武汉 430074；b中南民族大学 化学与材料科学学院，湖北 武汉 430074; c中国科学院上海生命科学学院，上海药物所，上海 201203) |
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| 摘 要： | 从人面果乙酸乙酯提取物中分离出5个新的口 山 酮 化合物garcinenone A (1), B (3), C (4), D (7) and E (8)和7个已知化合物，其结构经过波谱技术，特别是2D-NMR技术来鉴定。Jacareubin (2), 1,4,6-trihydroxy-5-methoxy-7-(3-methyl-2-buteny1)xanthone (6), subeliptenone B (11) 和symphoxanthone (12)为首次从该植物中分离出来。在DPPH自由基的清除活性实验中，所有的化合物都显示抗氧化活性，其IC50的值在 6.0-23.2 mM。结果表明人面果是潜在的有前景的天然抗氧化剂。
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| 关 键 词： | 藤黄属 大叶藤黄 口 山 酮 抗氧化活性 |
| 收稿时间： | 2008-03-12 |
| 修稿时间： | 2008-07-01 |
Xanthones from the Bark of Garcinia xanthochymus and Their 1,1‐Diphenyl‐2‐picrylhydrazyl Radical‐Scavenging Activity |
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| Fangfang ZHONG,Yu CHEN,Ping WANG,Huijin FENG,Guangzhong YANG. Xanthones from the Bark of Garcinia xanthochymus and Their 1,1‐Diphenyl‐2‐picrylhydrazyl Radical‐Scavenging Activity[J]. Chinese Journal of Chemistry, 2009, 27(1): 74-80. DOI: 10.1002/cjoc.200990029 |
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| Authors: | Fangfang ZHONG Yu CHEN Ping WANG Huijin FENG Guangzhong YANG |
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| Affiliation: | 1. Laboratory for Natural Product Chemistry, College of Life Sciences, South Central University for Nationalities, Wuhan, Hubei 430074, China;2. College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan, Hubei 430074, China;3. Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;4. Tel.: 0086‐027‐67842689;5. Fax: 0086‐027‐67842689 |
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| Abstract: | Five new xanthones, garcinenone A ( 1 ), B ( 3 ), C ( 4 ), D ( 7 ) and E ( 8 ), along with 7 known compounds were isolated from the EtOAc‐soluble extract of the bark of Garcinia xanthochymus, and their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Jacareubin ( 2 ), 1,4,6‐trihydroxy‐5‐methoxy‐7‐(3‐methyl‐2‐butenyl)xanthone ( 6 ), subeliptenone B ( 11 ) and symphoxanthone ( 12 ) were obtained from this plant for the first time. The isolated compounds exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging test with IC50 values in the 6.0–23.2 µmol/L. These results suggested that G. xanthochymus could be a promising rich source of natural antioxidant. |
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| Keywords: | Garcinia Garcinia xanthochymus xanthone antioxidant activity |
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