Preparation of samarium-153-EDTMP and determination of its radiochemical purity using paper chromatography |
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| Authors: | Haroldo Taurian Gasiglia Helena Okada |
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| Institution: | (1) Instituto de Pesquisas Energéticas e Nucleares, Comissão Nacional de Energia Nuclear/SP, Pinheiros, Caixa Postal 11049, 05422-970 São Paulo, SP, Brazil |
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| Abstract: | Samarium-153-ethylenediaminetetramethylenephosphonate (153Sm-EDTMP) has been used to palliate pain resulting from bone cancer. This paper describes the preparation of153SmCl3 from irradiated natural samarium and the ability of153Sm to complex with EDTMP in liquid and in freeze-dried forms. The evaluation of radiolabeled EDTMP was done by paper chromatography. A rapid evaluation of free153SmCl3 and153Sm-EDTMP was developed using a miniaturized chromatographic system. |
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