| PRIMARY AMINE DRUG SELECTIVE ELECTRODES WITH SPECIAL CROWN ETHERS AS NEUTRAL CARRIERS* |
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| 作者姓名： | 刘昆元 俞汝勤 |
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| 作者单位： | Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410012，PRC，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410012，PRC |
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| 基金项目： | Project supported by the Science Foundation of the National Education Council, China. Part of work was done in Electroanalytical Chemistry Laboratory, Changchun Institute of Applied Chemistry, Academia Sinica. |
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| 摘 要： | Ionophores selectively sensitive to primary amines have been synthesized which display low potentiometric selectivity coefficients for K~+, Na~+ and NH_4~+ ions, secondary and tertiary amines as well as quaternary ammonium ions. These ionophores include macrocyclic polyethers with dinaphthyl subunits and azocrown ether with nitrogen donor atoms. The feasibility of these ionophores for preparing primary amine drug selective electrodes was investigated in detail. Practically usable PVC membrane electrodes sensitive to primary amine drugs, such as mexiletine, dopamine, metaraminol and tryptamine, and aliphatic primary amines have been prepared with these ionophores as neutral carriers. Direct potentiometric methods for assaying these drugs have been proposed by using the prepared electrodes. The proposed primary amine drug selective electrodes are remarkably superior to those based on ion-associates. Compared with the electrodes based on common ethers, the interference by K~+, Na~+ and NH_4~+ ions is subst
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PRIMARY AMINE DRUG SELECTIVE ELECTRODES WITH SPECIAL CROWN ETHERS AS NEUTRAL CARRIERS* |
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| LIU KUN-YUAN AND YU RU-QIN.PRIMARY AMINE DRUG SELECTIVE ELECTRODES WITH SPECIAL CROWN ETHERS AS NEUTRAL CARRIERS*[J].Science in China(Chemistry),1990(12). |
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| Authors: | LIU KUN-YUAN AND YU RU-QIN |
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| Abstract: | Ionophores selectively sensitive to primary amines have been synthesized which display low potentiometric selectivity coefficients for K~+, Na~+ and NH_4~+ ions, secondary and tertiary amines as well as quaternary ammonium ions. These ionophores include macrocyclic polyethers with dinaphthyl subunits and azocrown ether with nitrogen donor atoms. The feasibility of these ionophores for preparing primary amine drug selective electrodes was investigated in detail. Practically usable PVC membrane electrodes sensitive to primary amine drugs, such as mexiletine, dopamine, metaraminol and tryptamine, and aliphatic primary amines have been prepared with these ionophores as neutral carriers. Direct potentiometric methods for assaying these drugs have been proposed by using the prepared electrodes. The proposed primary amine drug selective electrodes are remarkably superior to those based on ion-associates. Compared with the electrodes based on common ethers, the interference by K~+, Na~+ and NH_4~+ ions is substantially reduced. A digital simulation of the electrochemical process concerning the membrane transport was performed and some interesting conclusions have been drawn. |
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| Keywords: | primary amine drug selective electrodes crown ethers with dinaphthyl subunits neutral carriers ionophores |
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