不同相对分子质量羟乙基纤维素对甲维盐微胶囊制备的影响

采用原位聚合法以三聚氰胺-甲醛树脂为壁材制备了甲维盐微胶囊。 探讨了不同黏均相对分子质量羟乙基纤维素作为乳化剂对微胶囊表面形貌、粒径及其分布、包覆率与载药量的影响，对使用不同黏均相对分子质量羟乙基纤维素作为乳化剂制备的微胶囊的释放性能进行了表征。 结果表明，以相对分子质量较小的羟乙基纤维素制备的微胶囊外形规则、致密且无黏连现象。 随羟乙基纤维素黏均相对分子质量的增加所得微胶囊的平均粒径及粒径分布逐渐增大，包覆率与载药量逐渐减小。 释放性能的研究表明，采用相对分子质量较小的羟乙基纤维素制备的微胶囊的释放性能较好。

Effect of Relative Molecular Mass of Hydroxyethyl Cellulose on the Preparation of Emamectin Benzoate Microcapsules

Using different viscosity average relative molecular mass of hydroxyethyl cellulose(HEC) as the emulsifier,microcapsules containing emamectin benzoate were prepared by in-situ polymerization.The factors affecting the surface morphology,the particle size and distribution,the encapsulation efficiency and the drug loading were investigated,and the release properties were determined.The results show that the morphology of the microcapsules made by small relative molecular mass HEC is uniform,dense and the micro...