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A novel synthesis of 2-(disubstituted amino)-5(4)phenylimidazoles |
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| Authors: | Tamio Nishimura Katsuo Nakano Shinji Shibamoto Koji Kitajima |
| Abstract: | The reaction of 1-phenyl-1,2-propanedione with 1,1-disubstituted guanidines in methanol yielded 2-(disubstituted amino)-4-hydroxy-4-methyl-4H-imidazoles (III). Compound III produced 5(4)methylimidazoles by catalytic hydrogenation and 5(4)chloromethylimidazoles (IV) by concentrated hydrochloric acid treatment. Solvolysis of IV in water and alcohols gave 5(4)hydroxymethyl- and 5(4)alkoxymethylimidazoles, respectively. |
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