Preparation and evaluation of <Superscript>131</Superscript>I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer

Authors:	Qinghua Xie Xia Li Guanquan Wang Xuan Hou Yujun Wang Hongbo Yu Changfa Qu Shunzhong Luo Yali Cui Chuanqin Xia Ruibing Wang

Affiliation:	1.College of Chemistry,Sichuan University,Chengdu,China;2.College of Mathematics,Sichuan University,Chengdu,China;3.Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang,China;4.Department of Nuclear Medicine,Harbin Medical University Cancer Hospital,Harbin,China;5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences,University of Macau,Taipa, Macau,China

Abstract:	Here we reported the radiolabeling and evaluation of a novel ¹³¹I-radiolabeled quercetin for the treatment of dedifferentiated thyroid cancers. The human thyroid cancer cell lines (FTC-133, TT and DRO) experienced much higher uptake of ¹³¹I-quercetin as compared to the free ¹³¹I. And the proliferation inhibition rate of ¹³¹I-quercetin on in vitro DRO cell line was 86.87 ± 7.15%. Biodistribution and SPECT analysis demonstrated that the injected radioactivity mainly accumulated in tumors. The tumor volume in the treatment group was dramatically inhibited in comparison with the control group.

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