Protection of radiation induced DNA damage by a newly developed molybdenum complex |
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| Authors: | Md. Selim Abhijit Saha Kalyan K. Mukherjea |
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| Affiliation: | 1.Department of Chemistry,Jadavpur University,Kolkata,India;2.UGC-DAE Consortium for Scientific Research, Kolkata Centre,Kolkata,India;3.Department of Chemistry,Vivekananda College,Kolkata,India |
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| Abstract: | Ionizing radiation, especially gamma (γ) radiation, is assumed to be very effective for DNA damage due to formation of free radicals. DNA damage and inhibition of DNA damage produced on irradiation with 60Co gamma source were characterized by fluorescence spectrometry. Reduced form of glutathione (GSH) and its novel molybdenum glutathione (MoG) complex were employed for the protection of γ-radiation induced DNA damage. The spectroscopic results of the present study showed that the MoG complex is more efficient in protecting the double stranded DNA in vitro compared to reduced form of GSH. |
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