Getting it together: signal transduction in G-protein coupled receptors by association of receptor domains |
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Affiliation: | 1. Merck Research Laboratories, West Point, PA 19486, USA |
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Abstract: | The mechanism of signal transduction by G-protein coupled receptors is unknown. Here, we propose that these receptors signal in a way that is qualitatively similar to that seen in the chemokine and endocrine hormone receptor families; the signal occurs when two domains of the receptor are brought together, although this is not the only requirement for signaling. |
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