| Abstract: | The complex formation between two polysaccharides, hyaluronic acid (Hyal) and its sulphated derivative (HyalS), and two metal ions, Cu2+ and Zn2+ was investigated in aqueous solution by thermodynamic and spectroscopic techniques. A stoichiometry for the complex species in solution was obtained. The bioactivity of the metal‐polysaccharide complexes was then evaluated in terms of their influence on endothelial cell migration and adhesion. The biological response of the complex species was found to be dependent of both the polysaccharide (Hyal or HyalS) and the metal ion (Cu2+ or Zn2+). |
