A closer view of an oncoprotein-tumor suppressor interaction |
| |
| Institution: | Address: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA |
| |
| Abstract: | The cellular response to DNA damage is coordinated by the p53 protein. Mdm2, an oncoprotein, inhibits p53 and promotes p53 degradation. A recent high-resolution structure of the Mdm2-p53 complex may aid the design of small molecules to disrupt this interaction, for use in investigating the interaction further and for designing anticancer drugs. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
