Solid-phase synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics |
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| Authors: | Li X Zhang L Zhang W Hall S E Tam J P |
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| Affiliation: | Sphinx Pharmaceuticals, A Division of Eli Lilly and Company, Cambridge, Massachusetts 02139, USA. |
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| Abstract: | A solid-phase method for the synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde. |
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