Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus

Authors:	Paola?Devoto author-information" > author-information__contact u-icon-before" > mailto:pdevoto@unica.it" title=" pdevoto@unica.it" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Giovanna?Flore,Pierluigi?Saba,Mauro?Fà,Gian?Luigi?Gessa

Affiliation:	(1) Department of Neuroscience, "B.B. Brodie" University of Cagliari, Italy;(2) Consiglio Nazionale delle Ricerche, Section of Cagliari, Institute of Neuroscience, Cagliari, Italy;(3) Centre of Excellence "Neurobiology of Addiction", University of Cagliari, Cagliari, Italy

Abstract:	Background Previous studies by our group suggest that extracellular dopamine (DA) and noradrenaline (NA) may be co-released from noradrenergic nerve terminals in the cerebral cortex. We recently demonstrated that the concomitant release of DA and NA could be elicited in the cerebral cortex by electrical stimulation of the locus coeruleus (LC). This study analyses the effect of both single train and repeated electrical stimulation of LC on NA and DA release in the medial prefrontal cortex (mPFC), occipital cortex (Occ), and caudate nucleus. To rule out possible stressful effects of electrical stimulation, experiments were performed on chloral hydrate anaesthetised rats.

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