Pyrazolo[4,3-e][1,2,4]triazines: purine analogues with electronic absorption in the visible region |
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Authors: | Mojzych Mariusz Rykowski Andrzej Wierzchowski Jacek |
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Affiliation: | Department of Chemistry, University of Podlasie, 3-Maja 54, Siedlce, Poland. |
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Abstract: | Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10(-3) -10(-5) M range. |
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