Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica |
| |
| Institution: | 1. Departamento de Diagnóstico por Imagem, Universidade Federal de São Paulo-UNIFESP, Brasil;2. Departamento de Neurologia, Universidade Federal de São Paulo-UNIFESP, Brasil;1. School of Medicine, University of Milano-Bicocca, Milan, Italy;2. Department of Diagnostic Radiology, H S.Gerardo Monza, Milan, Italy;3. Department of Pathology, San Gerardo Hospital, Milan, Italy;1. Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC;2. Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ROC;3. Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC;4. Graduate Institute of Clinical Medcine, Taipei Medical University, Taipei, Taiwan, ROC;1. School of Biomedical Engineering, Southern Medical University, Guangzhou, China;2. Department of Diagnostic Imaging Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China;3. Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China;1. Dept. of Biomedical Engineering, Brno Univ. of Technology, Brno, Czech Republic;2. Inst. of Information Theory and Automation of the Academy of Sciences of the Czech Republic, Prague, Czech Republic;3. Inst. of Scientific Instruments of the Academy of Sciences of the Czech Republic, Brno, Czech Republic;4. Masaryk Memorial Cancer Institute, Dept. of Radiology, Brno, Czech Republic;5. Dept. of Biomedicine, Univ. of Bergen, Bergen, Norway;6. Dept. of Radiology, Haukeland University Hospital, Bergen, Norway;1. Radiology Department, Beijing Hospital, the Fifth Affiliated College of Peking University, Beijing, China;2. Radiology Department, Beijing Chaoyang Hospital, the Affiliated College of Capital Medical University, Beijing, China;3. Philips Healthcare, Andover, MA, USA |
| |
| Abstract: | BackgroundPrevious studies have demonstrated a correlation between Expanded Disability Status Scale (EDSS) and Diffusion Tensor Imaging (DTI) metrics, but the conclusions were based on evaluations of the entire cervical spinal cord.ObjectivesThe purpose of this study was to quantify the FA and MD values in the spinal cord of NMO patients, separating the lesion sites from the preserved sites, which has not been previously preformed. In addition, we attempted to identify a correlation with EDSS.MethodsDTI was performed in 11 NMO patients and 11 healthy individuals using a 1.5-T MRI scanner. We measured the FA and MD at ROIs positioned along the cervical spinal cord. The mean values of FA and MD at lesion, preserved and spinal cord sites were compared with those of a control group. We tested the correlations between the mean FA and MD with EDSS.ResultsFA in NMO patients was significantly reduced in lesion sites (0.44 vs. 0.55, p = 0.0046), preserved sites (0.46 vs. 0.55, p = 0.0015), and all sites (0.45 vs 0.55, p = 0.0013) while MD increased only in lesion sites (1.03 × 10? 3 mm2/s vs. 0.90 × 10? 3 mm2/s, p = 0.009). The FA demonstrated the best correlation with EDSS (r = ? 0.7603, p = 0.0086), particularly at lesion sites.ConclusionsThe results reinforce the importance of the FA index and confirm the hypothesis that NMO is a diffuse disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
