A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides |
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| Authors: | Liu Longbin Frohn Mike Xi Ning Dominguez Celia Hungate Randy Reider Paul J |
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| Institution: | Chemical Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. lliu@amgen.com |
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| Abstract: | reaction: see text] CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxyquinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported. |
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