HIV-1 integrase inhibition of biscoumarin analogues |
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| Authors: | Su Chang-Xiao Mouscadet Jean-Francois Chiang Chih-Chia Tsai Hou-Jen Hsu Ling-Yih |
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| Affiliation: | School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, ROC. |
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| Abstract: | Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents. |
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