Synthesis and Anti‐HIV Activity of Triazolo‐Fused 2′,3′‐Cyclic Nucleoside Analogs Prepared by an Intramolecular Huisgen 1,3‐Dipolar Cycloaddition |
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| Authors: | Jingbo Sun Ronghui Duan Hongming Li Jinchang Wu |
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| Institution: | 1. College of Chemistry, Jilin University, Changchun 130012, P.?R. China, (phone: +86‐15044068371;2. fax: +86‐431‐85195516) |
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| Abstract: | Triazolo‐fused 2′,3′‐cyclic nucleoside analogs were synthesized by an intramolecular 1,3‐dipolar cycloaddition of nucleoside‐derived azido alkynes in a regio‐ and stereospecific manner. The uracil base in these target compounds was successfully transformed to the corresponding cytosine. The synthesized compounds were examined in a MAGI assay for their anti‐HIV activities, and in a H9 T lymphocytes assay for their cell toxicities. |
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| Keywords: | Nucleosides Triazolo‐fused 2′ 3′ ‐cyclic nucleoside analogs Huisgen 1 3‐dipolar cycloaddition Cycloadditions Anti‐HIV Activity 2′ 3′ ‐Cyclic nucleosides |
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