Regioselective [3+3] Cyclization of 1,3‐Bis(silyloxy)buta‐1,3‐dienes with 1,1,1‐Trifluoro‐4‐(silyloxy)alk‐3‐en‐2‐ones: New and Convenient Synthesis of Functionalized 5‐Alkyl‐3‐(trifluoromethyl)phenols |
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| Authors: | Stefan Büttner Alina Bunescu Sebastian Reimann T H Tam?Dang Thomas Pundt Renske Klassen Andreas Schmidt Nazken K Kelzhanova Zharylkasyn A Abilov Tariel V Ghochikyan Ashot S Saghiyan Alexander Villinger Helmut Reinke Anke Spannenberg Peter Langer |
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| Institution: | 1. Institut für Chemie, Universit?t Rostock, Albert‐Einstein‐Str. 3a, DE‐18059 Rostock, (fax: +381?4986412);2. Leibniz‐Institut für Katalyse e.V. an der Universit?t Rostock, Albert‐Einstein‐Str. 29a, DE‐18059 Rostock;3. Al‐Farabi Kazakh National University, Al‐Farabi ave. 71, 050040 Almaty, Kazakhstan;4. Faculty of Chemistry, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, Armenia;5. CJSC Scientific Research Institute of Biotechnology, Gyurjyan Str. 14, 0056, Yerevan, Armenia |
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| Abstract: | Functionalized 5‐alkyl‐3‐(trifluoromethyl)phenols were prepared by formal 3+3] cyclization of 1,3‐bis(silyloxy)buta‐1,3‐dienes with 1,1,1‐trifluoro‐4‐(silyloxy)alk‐3‐en‐2‐ones derived from 1,1,1‐trifluoroalkane‐2,4‐diones. The latter were prepared by condensation of the dianion of 1,1,1‐trifluoropentane‐2,4‐dione with alkyl halides. |
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| Keywords: | Cyclization reactions Organofluorine compounds Silyl enol ethers Fluorine compounds X‐Ray crystallography |
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