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Stereoselective Total Synthesis of Multiplolide A and of a Diastereoisomer |
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| Authors: | Bandi Chennakesava Reddy Vikas Madhukar Bangade Palakuri Ramesh Harshadas Mitaram Meshram |
| Institution: | Discovery Laboratory, Organic Chemistry Division – I, Indian Institute of Chemical Technology, Hyderabad – 500?007, India (fax: +91‐40‐27160512) |
| Abstract: | A stereoselective total synthesis of multiplolide A ( 1 ) and of its diastereoisomer 2 was described from easily accessible starting materials (Schemes 2–4). The synthetic strategy involves a Jacobsen resolution, Sharpless epoxidation, Swern oxidation, Yamaguchi reaction, and ring‐closing metathesis (RCM). |
| Keywords: | Antifungal activity Multiplolide A Jacobsen resolution Sharpless epoxidation Ring‐closing metathesis (RCM) Swern oxidation Yamaguchi reaction |