Analysis of Sulfonamides by Liquid Chromatography Mass Spectrometry and Capillary Electrophoresis Combing with Voltage‐Assisted Liquid‐Phase Microextraction |
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Authors: | Mi‐Hung Wang Heng‐Wei Chang Shu‐Ping Wang |
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Affiliation: | Department of Applied Chemistry, Providence University, Shalu, Taichung City 43301, Taiwan |
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Abstract: | The method of liquid‐phase microextraction assisted with voltage was developed and applied on determination of sulfonamides in water samples. Four analytes, such as sulfamethazine, sulfathiazole, sulfadimethoxine, and sulfamethoxazole were extracted from a sample solution at pH 4.5 through a polypropylene membrane of immobilized with 2‐octanone, and then into 25 μL of the acceptor phase of 10 mM sodium hydroxide, and applied voltage of 100 V. Subsequently, the acceptor solution was directly subjected to analysis by LC‐MS or capillary zone electrophoresis. Linearity was obtained in the range of 1.0–25.0 ng mL?1 with R2 > 0.992 in LC‐MS, and 50–1000 ng mL?1 with R2 > 0.995 in capillary zone electrophoresis. The development of VA‐LPME was also applied in analysis of sulfonamides in water samples to evaluate its practical applicability. |
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Keywords: | Voltage‐assisted liquid‐phase microextraction Sulfonamides Capillary electrophoresis LC‐MS |
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