Development of a Carbon Nanotube Modified Ionic Liquid Electrode for the Voltammetric Determination of Methyldopa Levels in Urine |
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Authors: | B Pérez‐Mella A Álvarez‐Lueje |
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Institution: | Bioelectrochemistry Laboratory, Chemical and Pharmaceutical Sciences Faculty, University of Chile, PO Box 233, Santiago 1, Chile |
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Abstract: | A glassy carbon electrode was modified with carbon nanotubes and the ionic liquid N‐butyl pyridinium trifluoromethyl methanesulfonate for the determination of methyldopa in urine samples. Methyldopa exhibited a well‐defined anodic signal over a broad pH range of 2–10 and the peak current increased approximately 100 fold over that of the unmodified electrode. Accordingly, a novel method for the determination of methyldopa was proposed using differential pulse voltammetry. The peak current was linear over a methyldopa concentration range from 21 to 2111 ng mL?1 with a LOD of 6.9 ng mL?1 and a LOQ of 7.4 ng mL?1. The method was applied to determine the excretion profile of methyldopa in urine without sample pretreatment. |
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Keywords: | Methyldopa Carbon nanotubes Ionic liquids Modified electrodes Voltammetry |
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