Dynamic Structural Transformation of Resveratrol‐Modified Stearate Liposomes Led to a Spontaneous Drug Release System |
| |
| Authors: | Li‐Chou Chen Shih‐Shan Lin Cun‐Zhao Li Hsiu‐Fu Hsu Yu‐Jong Weng Chien‐Chung Cheng |
| |
| Affiliation: | 1. Department of Applied Chemistry, National Chia‐Yi University, Chia‐Yi City, Taiwan 60004, ROC;2. Department of Chemistry, Tamkang University, New Taipei City, Taiwan 25137, ROC;3. Division of Gastroenterology, Department of Internal Medicine, Chia‐Yi Veterans Hospital, Chia‐Yi City, Taiwan, ROC |
| |
| Abstract: | A mono‐substituted resveratrol derivative, resveratrol‐modified stearate (RMS), was synthesized by selectively coupling of stearic acid to the monohroxyphenyl of resveratrol in order to enhance both the stability and bioavailability of resveratrol. The RMS self‐assembles into liposomes and a series of suprastructural transformations into metastable helical ribbon, linear wire‐like structures, and inert spherical nanoparticles were detected that may be induced by the hydrogen‐bonding interactions. As a model for drug‐release investigations, gold nanoparticles (AuNPs) were encapsulated successfully by RMS to generate vesicles and succeed to release AuNPs druing the transformation to a ribbon‐like metastable stucture at ambient temperature. |
| |
| Keywords: | Liposome Resveratrol Stearate Helical transformation Drug‐release |
|
|
